FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY

نویسندگان

  • ALI AKBAR POURFATHOLLAH From the 'Experimental Hematology and Blood Banking Dept, Medical Sciences School, Tarbiat ModaresUniversity (T.M. U.),
  • HABIBOLLAH ESMAILI 4Community Medicine and Public Health Department of Mashhad Medical Sciences University, Mashhad, Iran
  • HASSAN MANSOURI TORGHABEH From the 'Experimental Hematology and Blood Banking Dept, Medical Sciences School, Tarbiat ModaresUniversity (T.M. U.),
  • MAHMOOD MAHMOODIAN SHOOSHTARI the Iranian Blood Transfusion Organization Research Center, Tehran
  • ZAHRA REZAIE YAZDI the Departmentof Internal Medicine, Mashhad Medical Sciences University, Mashhad
چکیده مقاله:

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII inhibitors and two patients had none. Because factor V and factor VIII share approximately 40% amino acid sequence homology in their A and C domains, it remains to be elucidated if it is one molecule that recognizes both factor V and VIII or whether there are two inhibitor molecules against common sites.

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عنوان ژورنال

دوره 18  شماره 4

صفحات  309- 313

تاریخ انتشار 2005-11

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